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ISL1 Antibody

CAT: 0223-58-426Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-426Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ISL1 is a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
NCBI Gene ID
3670
Swiss Prot
P61371
Accession Number
P61371
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ISL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ISL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Zebrafish, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ISL1
NCBI Official Name
Insulin gene enhancer protein ISL-1
NCBI Organism
Homo sapiens
Background Reference 01
De Luca, A., et al. Clin. Genet. (2010) In press :
Background Reference 02
Davis, O.S., et al. Behav. Genet. (2010) In press :
Background Reference 03
Genead, R., et al. Stem Cell Res 4 (1) :69-76 (2010)
Background Reference 04
Stevens, K.N., et al. PLoS ONE (5), E10855 (2010) :
Other Product Names
Insulin gene enhancer protein ISL-1, Islet-1, ISL1
Tested Applications
WB
Protein ID
47606423
Physical Properties
Liquid

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