ISL1 Antibody

• Background:

  ISL1 is a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

• NCBI Gene ID:

  3670

• Swiss Prot:

  P61371

• Accession Number:

  P61371

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ISL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ISL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken, Zebrafish, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ISL1

• NCBI Official Name:

  Insulin gene enhancer protein ISL-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  De Luca, A., et al. Clin. Genet. (2010) In press :

• Background Reference 02:

  Davis, O.S., et al. Behav. Genet. (2010) In press :

• Background Reference 03:

  Genead, R., et al. Stem Cell Res 4 (1) :69-76 (2010)

• Background Reference 04:

  Stevens, K.N., et al. PLoS ONE (5), E10855 (2010) :

• Other Product Names:

  Insulin gene enhancer protein ISL-1, Islet-1, ISL1

• Tested Applications:

  WB

• Protein ID:

  47606423

• Physical Properties:

  Liquid