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SFTPB Antibody

CAT: 0223-58-400Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-400Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SFTPB is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
NCBI Gene ID
6439
Swiss Prot
P07988
Accession Number
P07988
Host
Rabbit
Reactivity
Human
Immunogen
This SFTPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-158 amino acids from the Central region of human SFTPB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SFTPB
NCBI Official Name
Pulmonary surfactant-associated protein B
NCBI Organism
Homo sapiens
Background Reference 01
Baekvad-Hansen, M., et al. Eur. Respir. J. (2010) In press :
Background Reference 02
Kim, W.J., et al. Eur. Respir. J. (2010) In press :
Background Reference 03
Schuurhof, A., et al. Pediatr. Pulmonol. 45 (6) :608-613 (2010)
Background Reference 04
Cho, M.H., et al. Respir. Res. 11, 30 (2010) :
Other Product Names
Pulmonary surfactant-associated protein B, SP-B, 18 kDa pulmonary-surfactant protein, 6 kDa protein, Pulmonary surfactant-associated proteolipid SPL (Phe), SFTPB, SFTP3
Tested Applications
WB
Protein ID
131418
Physical Properties
Liquid

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