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SFTPC Antibody

CAT: 0223-57-199Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-199Size:400 µL
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Background
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
NCBI Gene ID
6440
Swiss Prot
P11686
Accession Number
P11686
Host
Rabbit
Reactivity
Human
Immunogen
This SFTPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human SFTPC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Symbol
SFTPC
NCBI Official Name
Pulmonary surfactant-associated protein C
NCBI Organism
Homo sapiens
Background Reference 01
Wambach, J.A., et al. Pediatr. Res. 68 (3) :216-220 (2010)
Background Reference 02
Schuurhof, A., et al. Pediatr. Pulmonol. 45 (6) :608-613 (2010)
Background Reference 03
Thouvenin, G., et al. Arch. Dis. Child. 95 (6) :449-454 (2010)
Background Reference 04
Crossno, P.F., et al. Chest 137 (4) :969-973 (2010)
Other Product Names
Pulmonary surfactant-associated protein C, SP-C, Pulmonary surfactant-associated proteolipid SPL (Val), SP5, SFTPC, SFTP2
Tested Applications
WB, IHC-P, IF
Protein ID
131425
Physical Properties
Liquid

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