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Mouse Cdk8 Antibody

CAT: 0223-58-365Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-365Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity) .
NCBI Gene ID
264064
Swiss Prot
Q8R3L8
Accession Number
Q8R3L8
Host
Rabbit
Reactivity
Human
Immunogen
This Mouse Cdk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-272 amino acids from the Central region of mouse Cdk8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Cdk8
NCBI Official Name
Cyclin-dependent kinase 8
NCBI Organism
Mus musculus
Background Reference 01
Alarcon, C., et al. Cell 139 (4) :757-769 (2009)
Background Reference 02
Westerling, T., et al. Mol. Cell. Biol. 27 (17) :6177-6182 (2007)
Background Reference 03
Jang, M.K., et al. Mol. Cell 19 (4) :523-534 (2005)
Background Reference 04
Tomomori-Sato, C., et al. J. Biol. Chem. 279 (7) :5846-5851 (2004)
Other Product Names
Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Cdk8
Tested Applications
WB
Physical Properties
Liquid

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