Mouse Mapk14 Antibody

• Background:

  Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression.

• NCBI Gene ID:

  26416

• Swiss Prot:

  P47811

• Accession Number:

  P47811

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Mouse Mapk14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of mouse Mapk14.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Mapk14

• NCBI Official Name:

  Mitogen-activated protein kinase 14

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Pan, W.W., et al. J. Biol. Chem. 285 (45) :34348-34354 (2010)

• Background Reference 02:

  Menon, M.B., et al. J. Biol. Chem. 285 (43) :33242-33251 (2010)

• Background Reference 03:

  Chandrakesan, P., et al. J. Biol. Chem. 285 (43) :33485-33498 (2010)

• Background Reference 04:

  Ferreiro, I., et al. J. Biol. Chem. 285 (41) :31819-31828 (2010)

• Other Product Names:

  Mitogen-activated protein kinase 14, MAP kinase 14, MAPK 14, CRK1, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Mapk14, Crk1, Csbp1, Csbp2

• Tested Applications:

  WB

• Physical Properties:

  Liquid