HMGCL Antibody

• Background:

  HMGCL belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  3155

• Swiss Prot:

  P35914

• Accession Number:

  P35914

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HMGCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the Central region of human HMGCL.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  HMGCL

• NCBI Official Name:

  Hydroxymethylglutaryl-CoA lyase, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fu, Z., et al. J. Biol. Chem. 285 (34) :26341-26349 (2010)

• Background Reference 02:

  Pierron, S., et al. Arch Pediatr 17 (1) :10-13 (2010)

• Background Reference 03:

  Menao, S., et al. Hum. Mutat. 30 (3), E520-E529 (2009) :

• Background Reference 04:

  Lin, W.D., et al. Clin. Chim. Acta 401 (1-2), 33-36 (2009) :

• Other Product Names:

  Hydroxymethylglutaryl-CoA lyase, mitochondrial, HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase, HMGCL

• Tested Applications:

  WB

• Protein ID:

  24418852

• Physical Properties:

  Liquid