CPT1C Antibody

• Background:

  The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.

• NCBI Gene ID:

  126129

• Swiss Prot:

  Q8TCG5

• Accession Number:

  Q8TCG5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CPT1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 596-625 amino acids from the C-terminal region of human CPT1C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  91 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CPT1C

• NCBI Official Name:

  Carnitine O-palmitoyltransferase 1, brain isoform

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 03:

  Roomets, E., et al. Invest. Ophthalmol. Vis. Sci. 49 (4) :1660-1664 (2008)

• Background Reference 04:

  Sierra, A.Y., et al. J. Biol. Chem. 283 (11) :6878-6885 (2008)

• Other Product Names:

  Carnitine O-palmitoyltransferase 1, brain isoform, CPT1-B, CPT IC, Carnitine O-palmitoyltransferase I, brain isoform, CPTI-B, Carnitine palmitoyltransferase 1C, CPT1C, CATL1

• Tested Applications:

  WB

• Protein ID:

  57013809

• Physical Properties:

  Liquid