CPT1A Antibody

CAT: 0223-57-900Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-900Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
1374
Swiss Prot
P50416
Accession Number
P50416
Host
Rabbit
Reactivity
Human
Immunogen
This CPT1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 728-756 amino acids from the C-terminal region of human CPT1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
88 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CPT1A
NCBI Official Name
Carnitine O-palmitoyltransferase 1, liver isoform
NCBI Organism
Homo sapiens
Background Reference 01
Gessner, B.D., et al. Pediatrics 126 (5) :945-951 (2010)
Background Reference 02
Collins, S.A., et al. Mol. Genet. Metab. 101 (2-3), 200-204 (2010) :
Background Reference 03
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 04
Song, S., et al. Mol. Cell. Endocrinol. 325 (1-2), 54-63 (2010) :
Other Product Names
Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1
Tested Applications
WB
Protein ID
56405343
Physical Properties
Liquid

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