CPT1A Antibody

• Background:

  The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1374

• Swiss Prot:

  P50416

• Accession Number:

  P50416

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CPT1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 728-756 amino acids from the C-terminal region of human CPT1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CPT1A

• NCBI Official Name:

  Carnitine O-palmitoyltransferase 1, liver isoform

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gessner, B.D., et al. Pediatrics 126 (5) :945-951 (2010)

• Background Reference 02:

  Collins, S.A., et al. Mol. Genet. Metab. 101 (2-3), 200-204 (2010) :

• Background Reference 03:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04:

  Song, S., et al. Mol. Cell. Endocrinol. 325 (1-2), 54-63 (2010) :

• Other Product Names:

  Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1

• Tested Applications:

  WB

• Protein ID:

  56405343

• Physical Properties:

  Liquid