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Mouse Syk Antibody

CAT: 0223-58-297Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-297Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Phosphorylates USP25 and regulates its intracellular levels (By similarity) .
NCBI Gene ID
20963
Swiss Prot
P48025
Accession Number
P48025
Host
Rabbit
Reactivity
Human
Immunogen
This Mouse Syk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of mouse Syk.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
71 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Syk
NCBI Official Name
Tyrosine-protein kinase SYK
NCBI Organism
Mus musculus
Background Reference 01
Heizmann, B., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (43) :18563-18568 (2010)
Background Reference 02
Fernandez, P.L., et al. J. Biol. Chem. 285 (43) :32844-32851 (2010)
Background Reference 03
Zou, W., et al. J. Cell. Sci. 123 (PT 17), 2955-2963 (2010) :
Background Reference 04
Falet, H., et al. J. Exp. Med. 207 (9) :1967-1979 (2010)
Other Product Names
Tyrosine-protein kinase SYK, Spleen tyrosine kinase, Syk, ptk72, Sykb
Tested Applications
WB
Physical Properties
Liquid

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