SYK Antibody

• Background:

  This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  6850

• Swiss Prot:

  P43405

• Accession Number:

  P43405

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SYK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-305 amino acids from human SYK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  72 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SYK

• NCBI Official Name:

  Tyrosine-protein kinase SYK

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Thomas, D.H., et al. Blood 116 (14) :2570-2578 (2010)

• Background Reference 02:

  Poeck, H., et al. J. Mol. Med. 88 (8) :745-752 (2010)

• Background Reference 03:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04:

  Pechloff, K., et al. J. Exp. Med. 207 (5) :1031-1044 (2010)

• Other Product Names:

  Tyrosine-protein kinase SYK, Spleen tyrosine kinase, p72-Syk, SYK

• Tested Applications:

  WB

• Protein ID:

  1174527

• Physical Properties:

  Liquid