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CPS1 Antibody

CAT: 0223-58-231Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-231Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.
NCBI Gene ID
1373
Swiss Prot
P31327
Accession Number
P31327
Host
Rabbit
Reactivity
Human
Immunogen
This CPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-291 amino acids from the N-terminal region of human CPS1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
165 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CPS1
NCBI Official Name
Carbamoyl-phosphate synthase [ammonia], mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :
Background Reference 03
Pekkala, S., et al. Hum. Mutat. 31 (7) :801-808 (2010)
Background Reference 04
Huo, R., et al. J. Biochem. Mol. Biol. 38 (1) :28-33 (2005)
Other Product Names
Carbamoyl-phosphate synthase [ammonia], mitochondrial, Carbamoyl-phosphate synthetase I, CPSase I, CPS1
Tested Applications
WB
Protein ID
4033707
Physical Properties
Liquid

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