FOLR3 Antibody

• Background:

  This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively.

• NCBI Gene ID:

  2352

• Swiss Prot:

  P41439

• Accession Number:

  P41439

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FOLR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human FOLR3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  FOLR3

• NCBI Official Name:

  Folate receptor gamma

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  O'Byrne, M.R., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (8) :689-694 (2010)

• Background Reference 02:

  Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Background Reference 03:

  Boyles, A.L., et al. Genet. Epidemiol. 33 (3) :247-255 (2009)

• Background Reference 04:

  Franke, B., et al. Birth Defects Res. PartClin. Mol. Teratol. 85 (3) :216-226 (2009)

• Other Product Names:

  Folate receptor gamma, FR-gamma, Folate receptor 3, FOLR3

• Tested Applications:

  WB

• Protein ID:

  1169723

• Physical Properties:

  Liquid