Connexin 37 Antibody

• Background:

  Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.

• NCBI Gene ID:

  2701

• Swiss Prot:

  P35212

• Accession Number:

  P35212

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Connexin 37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-333 amino acids from the C-terminal region of human Connexin 37.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein G column, followed by dialysis against PBS.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GJA4

• NCBI Official Name:

  Gap junction alpha-4 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

• Background Reference 02:

  Saito, T., et al., Int. J. Cancer 86 (1) :67-70 (2000) .

• Background Reference 03:

  Boerma, M., et al., J. Intern. Med. 246 (2) :211-218 (1999) .

• Background Reference 04:

  Krutovskikh, V., et al., Carcinogenesis 17 (8) :1761-1763 (1996) .

• Other Product Names:

  Gap junction alpha-4 protein, Connexin-37, Cx37, GJA4

• Tested Applications:

  WB, IHC-P

• Protein ID:

  8928555

• Physical Properties:

  Liquid