Connexin 31 Antibody

• Background:

  Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

• NCBI Gene ID:

  2707

• Swiss Prot:

  O75712

• Accession Number:

  O75712

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  31 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GJB3

• NCBI Official Name:

  Gap junction beta-3 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mhatre, A.N., et al., Clin. Genet. 63 (2) :154-159 (2003) .

• Background Reference 02:

  Diestel, S., et al., Biochem. Biophys. Res. Commun. 296 (3) :721-728 (2002) .

• Background Reference 03:

  Di, W.L., et al., Hum. Mol. Genet. 11 (17) :2005-2014 (2002) .

• Background Reference 04:

  Gottfried, I., et al., Hum. Mol. Genet. 11 (11) :1311-1316 (2002) .

• Other Product Names:

  Gap junction beta-3 protein, Connexin-31, Cx31, GJB3, CX31

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid