Connexin 43 Antibody

• Background:

  Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.

• NCBI Gene ID:

  2697

• Swiss Prot:

  P17302

• Accession Number:

  P17302

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This Connexin 43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-138 amino acids from the N-terminal region of human Connexin 43.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein G column, followed by dialysis against PBS.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Xenopus, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GJA1

• NCBI Official Name:

  Gap junction alpha-1 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Spinella, F., et al., J. Biol. Chem. 278 (42) :41294-41301 (2003) . Contreras, J.E., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (20) :11388-11393 (2003) . Qin, H., et al., J. Biol. Chem. 278 (32) :30005-30014 (2003) . Cameron, S.J., et al., J. Biol. Chem. 278 (20) :18682-18688 (2003) . Ma, X.D., et al., World J. Gastroenterol. 9 (5) :946-950 (2003) .

• Other Product Names:

  Gap junction alpha-1 protein, Connexin-43, Cx43, Gap junction 43 kDa heart protein, GJA1, GJAL

• Tested Applications:

  WB

• Protein ID:

  117706

• Physical Properties:

  Liquid