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MXI1 Antibody

CAT: 0223-58-142Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-142Size:400 µL
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Background
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
NCBI Gene ID
4601
Swiss Prot
P50539
Accession Number
P50539
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the Central region of human MXI1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MXI1
NCBI Official Name
Max-interacting protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Lofstedt, T., et al. Exp. Cell Res. 315 (11) :1924-1936 (2009)
Background Reference 02
Baranzini, S.E., et al. Hum. Mol. Genet. 18 (4) :767-778 (2009)
Background Reference 03
Tsao, C.C., et al. Cancer Biol. Ther. 7 (10) :1619-1627 (2008)
Background Reference 04
Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28 (11) :745-749 (2007)
Other Product Names
Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11
Tested Applications
WB
Protein ID
116242666
Physical Properties
Liquid

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