HRH2 Antibody

• Background:

  Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  3274

• Swiss Prot:

  P25021

• Accession Number:

  P25021

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HRH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the Central region of human HRH2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  40 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  HRH2

• NCBI Official Name:

  Histamine H2 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Ruano, G., et al. Pharmacogenomics 11 (7) :959-971 (2010) Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010) Szukiewicz, D., et al. Inflamm. Res. 59 SUPPL 2, S205-S207 (2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Other Product Names:

  Histamine H2 receptor, H2R, HH2R, Gastric receptor I, HRH2

• Tested Applications:

  WB

• Protein ID:

  123120

• Physical Properties:

  Liquid