GLRB Antibody

CAT: 0223-58-104Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-104Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
2743
Swiss Prot
P48167
Accession Number
P48167
Host
Rabbit
Reactivity
Human
Immunogen
This GLRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the N-terminal region of human GLRB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GLRB
NCBI Official Name
Glycine receptor subunit beta
NCBI Organism
Homo sapiens
Background Reference 01
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)
Background Reference 02
Wheeler, H.E., et al. PLoS Genet. (10), E1000685 (2009) :
Background Reference 03
Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380 (4) :277-291 (2009)
Background Reference 04
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
Other Product Names
Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB
Tested Applications
WB
Protein ID
1346173
Physical Properties
Liquid

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