FXYD5 Antibody

CAT: 0223-58-089Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-089Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel) . FXYD2, also known as the gamma subunit of the Na, K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., [email protected].].
NCBI Gene ID
53827
Swiss Prot
Q96DB9
Accession Number
Q96DB9
Host
Rabbit
Reactivity
Human
Immunogen
This FXYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the Central region of human FXYD5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Symbol
FXYD5
NCBI Official Name
FXYD domain-containing ion transport regulator 5
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Ono, K., et al. Anticancer Res. 30 (9) :3273-3278 (2010)
Background Reference 03
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Background Reference 04
Liang, J.F., et al. Pathol. Res. Pract. 205 (7) :445-450 (2009)
Other Product Names
FXYD domain-containing ion transport regulator 5, Dysadherin, FXYD5, DYSAD, IWU1
Tested Applications
WB, IHC-P
Protein ID
311033386
Physical Properties
Liquid

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