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FXYD7 Antibody

CAT: 0223-6465-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6465-01Size:0.02 mg
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Background
FXYD7 Antibody: FXYD7 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing seven invariant and six highly conserved amino acids. The FXYD proteins are tissue-specific regulators of Na, K-ATPase, with FXYD7 initially identified as a brain-specific member. FXYD7 interacts with Na, K-ATPase through its transmembrane domain and is thought to influence the affinity of Na, K-ATPase for external K+ and Na+ ions. Other members of the FXDY family have similar functions: FXYD2 regulates the properties of Na, K-ATPase, while FXYD1 (phospholemman), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.
NCBI Gene ID
53822
Swiss Prot
P58549
Accession Number
AAH18619
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
FXYD7 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (71%)
Buffer
FXYD7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FXYD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
FXYD7 antibody is human, mouse and rat reactive. FXYDY7 antibody is predicted to not react with other members of the FXDY protein family
Symbol
FXYD7
NCBI Official Name
FXYD domain containing ion transport regulator 7
NCBI Organism
Homo sapiens
Background Reference 01
Beguin P, Crambert G, Monnet-Tschudi F, et al. FXYD7 is a brain-specific regulator of Na, K-ATPase alpha1-beta isozymes. EMBO J. 2002; 21:3264-73
Background Reference 02
Crambert G and Geering K. FXYD proteins: new tissue-specific regulators of the ubiquitous Na, K-ATPase. Sci. STKE 2003; 2003 (166) :RE1.
Background Reference 03
Li C, Crambert G, Thuillard D, et al. role of the transmembrane domain of FXDY7 in structural and functional interactions with Na, K-ATPase. J. Biol. Chem. 2005; 280:42738-43.
Other Product Names
FXYD7 Antibody: FXYD domain-containing ion transport regulator 7
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
11612659
Physical Properties
Liquid

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