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KCND2 Antibody

CAT: 0223-58-024Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-024Size:400 µL
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Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.
NCBI Gene ID
3751
Swiss Prot
Q9NZV8
Accession Number
Q9NZV8
Host
Rabbit
Reactivity
Human
Immunogen
This KCND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-151 amino acids from the N-terminal region of human KCND2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
71 kDa
Fragment
Rabbit Ig
Symbol
KCND2
NCBI Official Name
Potassium voltage-gated channel subfamily D member 2
NCBI Organism
Homo sapiens
Background Reference 01
Foeger, N.C., et al. J. Biol. Chem. 285 (43) :33413-33422 (2010)
Background Reference 02
Levy, D.I., et al. J. Physiol. (Lond.) 588 (PT 14), 2657-2668 (2010) :
Background Reference 03
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 04
Aronica, E., et al. Neurobiol. Dis. 36 (1) :81-95 (2009)
Other Product Names
Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit Kv42, KCND2, KIAA1044
Tested Applications
WB, IHC-P
Protein ID
38258257
Physical Properties
Liquid

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