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KCNQ2 Antibody

CAT: 0223-28-295Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-28-295Size:100 µL
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Background
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1) .
NCBI Gene ID
3785
Swiss Prot
Q5VYU0
Accession Number
NP_742107
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNQ2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Neuroscience
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store KCNQ2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
43 kDa
Applications Notes
KCNQ2 antibody can be used for detection of KCNQ2 by ELISA at 1:62500. KCNQ2 antibody can be used for detection of KCNQ2 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
KCNQ2
NCBI Official Name
Potassium voltage-gated channel, KQT-like subfamily, member 2
NCBI Organism
Homo sapiens
Background Reference 01
Tang, B., et al., (2004) J. Neurol. Sci. 221 (1-2), 31-34.
Other Product Names
KCNQ2, EBN, BFNC, EBN1, ENB1, BFNS1, EIEE7, HNSPC, KV7.2, KCNA11, KVEBN1
Tested Applications
ELISA, WB, IHC
Protein ID
26051268
Physical Properties
Liquid

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