KCNN2 Antibody

KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.

3781

Q6PJI0

NP_740721

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNN2.

Unconjugated

Primary Antibodies

Membrane, Signal Transduction

Antibody is purified by peptide affinity chromatography method.

Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store KCNN2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

26 kDa

KCNN2 antibody can be used for detection of KCNN2 by ELISA at 1:62500. KCNN2 antibody can be used for detection of KCNN2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

KCNN2

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

Homo sapiens

Morimoto, T., (2007) J. Pharmacol. Sci. 104 (1), 94-98.

KCNN2, KCa2.2, SK2, SKCA2, hSK2, SKCa 2

ELISA, WB

25777647