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PTPRG Antibody

CAT: 0223-58-007Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-007Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
NCBI Gene ID
5793
Swiss Prot
P23470
Accession Number
P23470
Host
Rabbit
Reactivity
Mouse
Immunogen
This PTPRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-700 amino acids from the Central region of human PTPRG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
162 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PTPRG
NCBI Official Name
Receptor-type tyrosine-protein phosphatase gamma
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Shu, S.T., et al. Anticancer Res. 30 (6) :1937-1946 (2010)
Background Reference 03
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34 (5) :800-812 (2010)
Background Reference 04
Bouyain, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (6) :2443-2448 (2010)
Other Product Names
Receptor-type tyrosine-protein phosphatase gamma, Protein-tyrosine phosphatase gamma, R-PTP-gamma, PTPRG, PTPG
Tested Applications
WB
Protein ID
229463033
Physical Properties
Liquid

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