PTPRF Antibody

CAT: 0223-19-666Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-19-666Size:100 µL
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
NCBI Gene ID
5792
Swiss Prot
P10586
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 30-190 of human PTPRF (NP_569707.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 150kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
PTPRF
Positive Control 2
THP-1
Positive Control 3
Mouse liver
NCBI Official Name
Protein tyrosine phosphatase, receptor type, F
NCBI Organism
Homo sapiens
Other Product Names
LAR, Receptor-type tyrosine-protein phosphatase F, Leukocyte common antigen related, LAR, Receptortype tyrosineprotein phosphatase F, LAR protein, Leukocyte antigen related
Tested Applications
WB
Physical Properties
Liquid

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