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KCNA3 Antibody

CAT: 0223-57-918Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-918Size:400 µL
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Background
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
NCBI Gene ID
3738
Swiss Prot
P22001
Accession Number
P22001
Host
Rabbit
Reactivity
Human
Immunogen
This KCNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the Central region of human KCNA3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KCNA3
NCBI Official Name
Potassium voltage-gated channel subfamily A member 3
NCBI Organism
Homo sapiens
Background Reference 01
Wang, T., et al. J. Neurosci. 30 (14) :5020-5027 (2010)
Background Reference 02
Tu, L.W., et al. J. Mol. Biol. 396 (5) :1346-1360 (2010)
Background Reference 03
Poulopoulou, C., et al. Neurobiol. Dis. 37 (2) :339-348 (2010)
Background Reference 04
Nicolaou, S.A., et al. Cell Calcium 47 (1) :19-28 (2010)
Other Product Names
Potassium voltage-gated channel subfamily A member 3, HGK5, HLK3, HPCN3, Voltage-gated K (+) channel HuKIII, Voltage-gated potassium channel subunit Kv13, KCNA3, HGK5
Tested Applications
WB
Protein ID
215274135
Physical Properties
Liquid

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