KCNJ3 Antibody

• Background:

  Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.

• NCBI Gene ID:

  3760

• Swiss Prot:

  P48549

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ3 (NP_002230.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Affinity purification

• Positive Control:

  Mouse brain

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 60kDa

• Fragment:

  IgG

• Symbol:

  KCNJ3

• Positive Control 2:

  Rat brain

• NCBI Official Name:

  Potassium voltage-gated channel subfamily J member 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  GIRK1, KGA, KIR3.1, G protein-activated inward rectifier potassium channel 1, GIRK-1, inward rectifier K (+) channel Kir3.1, inward rectifier K+ channel KIR3.1, potassium channel, inwardly rectifying subfamily J member 3, potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e, potassium inwardly-rectifying channel, subfamily J, member 3

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid