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KCNAB3 Antibody

CAT: 0223-59-918Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-918Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member and the KCNA5 gene product assemble into a heteromultimeric A-type channel that inactivates completely and is significantly faster than other A-type Kv channels.
NCBI Gene ID
9196
Swiss Prot
O43448
Accession Number
O43448
Host
Rabbit
Reactivity
Human
Immunogen
This KCNAB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-204 amino acids from the Central region of human KCNAB3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KCNAB3
NCBI Official Name
Voltage-gated potassium channel subunit beta-3
NCBI Organism
Homo sapiens
Background Reference 01
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 02
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 03
Leicher, T., et al. J. Biol. Chem. 273 (52) :35095-35101 (1998)
Background Reference 04
McCormack, K., et al. FEBS Lett. 370 (1-2), 32-36 (1995) :
Other Product Names
Voltage-gated potassium channel subunit beta-3, K (+) channel subunit beta-3, Kv-beta-3, KCNAB3, KCNA3B
Tested Applications
WB
Physical Properties
Liquid

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