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KCNA4 Antibody

CAT: 0223-60-814Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-814Size:400 µL
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Background
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
NCBI Gene ID
3739
Swiss Prot
P22459
Accession Number
P22459
Host
Rabbit
Reactivity
Human
Immunogen
This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
73 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KCNA4
NCBI Official Name
Potassium voltage-gated channel subfamily A member 4
NCBI Organism
Homo sapiens
Background Reference 01
Schwetz, T.A., et al. Biochim. Biophys. Acta 1798 (3) :367-375 (2010)
Background Reference 02
Angelova, P.R., et al. Eur. J. Neurosci. 29 (10) :1943-1950 (2009)
Background Reference 03
Mckeown, L., et al. J. Biol. Chem. 283 (44) :30421-30432 (2008)
Background Reference 04
Lee, J.H., et al. Mol. Pharmacol. 73 (3) :619-626 (2008)
Other Product Names
Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K (+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv14, KCNA4, KCNA4L
Tested Applications
WB
Protein ID
313104127
Physical Properties
Liquid

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