RUNX3 Antibody

• Background:

  This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  864

• Swiss Prot:

  Q13761

• Accession Number:

  Q13761

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RUNX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the Central region of human RUNX3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  RUNX3

• NCBI Official Name:

  Runt-related transcription factor 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tsang, Y.H., et al. Oncogene 29 (41) :5643-5650 (2010)

• Background Reference 02:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 03:

  Iwatani, K., et al. Biochem. Biophys. Res. Commun. 400 (3) :426-431 (2010)

• Background Reference 04:

  Kodach, L.L., et al. Carcinogenesis 31 (9) :1567-1575 (2010)

• Other Product Names:

  Runt-related transcription factor 3, Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3, CBF-alpha-3, Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit, PEA2-alpha C, PEBP2-alpha C, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, RUNX3, AML2, CBFA3, PEBP2A3

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  17368453

• Physical Properties:

  Liquid