RUNX1 Antibody

• Background:

  Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with severaltypes of leukemia.

• NCBI Gene ID:

  861

• Swiss Prot:

  Q01196

• Accession Number:

  AAC05247

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RUNX1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store RUNX1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  12 kDa

• Applications Notes:

  RUNX1 antibody can be used for detection of RUNX1 by ELISA at 1:12500. RUNX1 antibody can be used for detection of RUNX1 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  RUNX1

• NCBI Official Name:

  Runt-related transcription factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ghozi, M.C., et al., (1996) Proc. Natl. Acad. Sci. U.S.A. 93 (5), 1935-1940.

• Other Product Names:

  RUNX1, AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1

• Tested Applications:

  ELISA, WB

• Protein ID:

  2944214

• Physical Properties:

  Liquid