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AML1 (RUNX1) Antibody

CAT: 0223-79-674Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-674Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.
NCBI Gene ID
861
Swiss Prot
Q01196
Accession Number
NP_001116079.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
AML1 (RUNX1) antibody was raised against a peptide sequence around aa.6~10 (D-A-S-T-S) derived from Human AML1 (RUNX1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
55 kDa
Specificity
This antibody detects endogenous level of total AML1 (RUNX1) protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
RUNX1
NCBI Official Name
Runt-related transcription factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Mao S., Frank R. C., Zhang J., Miyazaki Y., Nimer S. D. Mol. Cell. Biol. 19:3635-3644 (1999) Pelletier N., Champagne N., Stifani S., Yang X. -J. Oncogene 21:2729-2740 (2002) Cho J. -Y., Akbarali Y., Zerbini L. F., Gu X., Boltax J., Wang Y., Oettgen P., Zhang D. -E., Libermann T. A. J. Biol. Chem. 279:19512-19522 (2004)
Other Product Names
AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1
Tested Applications
WB
Protein ID
169790837
Physical Properties
Liquid

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