Mouse Acvr1c Antibody

• Background:

  Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

• NCBI Gene ID:

  269275

• Swiss Prot:

  Q8K348

• Accession Number:

  Q8K348

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 amino acids from the C-terminal region of mouse Acvr1c.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Human, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Acvr1c

• NCBI Official Name:

  Activin receptor type-1C

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Andersson, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (20) :7252-7256 (2008)

• Background Reference 02:

  Bertolino, P., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (20) :7246-7251 (2008)

• Background Reference 03:

  Liguori, G.L., et al. Dev. Biol. 315 (2) :280-289 (2008)

• Background Reference 04:

  Kurrasch, D.M., et al. J. Neurosci. 27 (50) :13624-13634 (2007)

• Other Product Names:

  Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Acvr1c {ECO:0000312|EMBL:AAH287801}

• Tested Applications:

  WB

• Physical Properties:

  Liquid