SNAP23 Antibody

• Background:

  Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

• NCBI Gene ID:

  8773

• Swiss Prot:

  O00161

• Accession Number:

  O00161

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SNAP23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-199 amino acids from the C-terminal region of human SNAP23.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  23 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SNAP23

• NCBI Official Name:

  Synaptosomal-associated protein 23

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Greaves, J., et al. J. Biol. Chem. 285 (32) :24629-24638 (2010)

• Background Reference 02:

  Bostrom, P., et al. Diabetes 59 (8) :1870-1878 (2010)

• Background Reference 03:

  Ban, H.J., et al. BMC Genet. 11, 26 (2010) :

• Background Reference 04:

  Kean, M.J., et al. J. Cell. Sci. 122 (PT 22), 4089-4098 (2009) :

• Other Product Names:

  Synaptosomal-associated protein 23, SNAP-23, Vesicle-membrane fusion protein SNAP-23, SNAP23

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid