GABRB2 Antibody

• Background:

  The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.

• NCBI Gene ID:

  2561

• Swiss Prot:

  P47870

• Accession Number:

  P47870

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GABRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-374 amino acids from the C-terminal region of human GAB_2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:500

• Symbol:

  GABRB2

• NCBI Official Name:

  Gamma-aminobutyric acid receptor subunit beta-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lo, W.Y., et al. J. Biol. Chem. 285 (41) :31348-31361 (2010)

• Background Reference 02:

  Green, E.K., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (7), 1347-1349 (2010) :

• Background Reference 03:

  Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :

• Background Reference 04:

  Chen, J., et al. Biochem. Soc. Trans. 37 (PT 6), 1415-1418 (2009) :

• Other Product Names:

  Gamma-aminobutyric acid receptor subunit beta-2, GABA (A) receptor subunit beta-2, GABRB2

• Tested Applications:

  WB

• Protein ID:

  292495010

• Physical Properties:

  Liquid