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GABRG2 Antibody

CAT: 0223-28-313Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-28-313Size:100 µL
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Background
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA (A) subunits. GABRG2 is the gamma 2 subunit of GABA (A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures.Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA (A) subunits. This gene encodes the gamma 2 subunit of GABA (A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.
NCBI Gene ID
2566
Swiss Prot
P18507
Accession Number
NP_944493
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GABRG2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store GABRG2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
36 kDa, 54 kDa, 55 kDa
Applications Notes
GABRG2 antibody can be used for detection of GABRG2 by ELISA at 1:62500. GABRG2 antibody can be used for detection of GABRG2 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
GABRG2
NCBI Official Name
Gamma-aminobutyric acid (GABA) A receptor, gamma 2
NCBI Organism
Homo sapiens
Background Reference 01
Sancar, F. (2004) J. Biol. Chem. 279 (45), 47034-47039.
Other Product Names
GABRG2, CAE2, ECA2, GEFSP3
Tested Applications
ELISA, WB
Protein ID
189083762
Physical Properties
Liquid

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