SEC23IP Antibody

• Background:

  COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway. [provided by RefSeq].

• NCBI Gene ID:

  11196

• Swiss Prot:

  Q9Y6Y8

• Accession Number:

  Q9Y6Y8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SEC23IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 724-752 amino acids from the C-terminal region of human SEC23IP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  111 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SEC23IP

• NCBI Official Name:

  SEC23-interacting protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ong, Y.S., et al. J. Cell Biol. 190 (3) :331-345 (2010)

• Background Reference 02:

  Trynka, G., et al. Gut 58 (8) :1078-1083 (2009)

• Background Reference 03:

  Li, H., et al. J. Biol. Chem. 281 (21) :14748-14755 (2006)

• Background Reference 04:

  Grupe, A., et al. Am. J. Hum. Genet. 78 (1) :78-88 (2006)

• Other Product Names:

  SEC23-interacting protein, p125, SEC23IP

• Tested Applications:

  WB

• Protein ID:

  55584014

• Physical Properties:

  Liquid