SHMT1 Antibody

• Background:

  This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.

• NCBI Gene ID:

  6470

• Swiss Prot:

  P34896

• Accession Number:

  P34896

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human SHMT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SHMT1

• NCBI Official Name:

  Serine hydroxymethyltransferase, cytosolic

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Porter, K.E., et al. Environ. Res. 110 (6) :580-587 (2010)

• Background Reference 02:

  Summers, C.M., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (8) :679-688 (2010)

• Background Reference 03:

  Vijayakrishnan, J., et al. Haematologica 95 (8) :1405-1414 (2010)

• Background Reference 04:

  Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19 (7) :1812-1821 (2010)

• Other Product Names:

  Serine hydroxymethyltransferase, cytosolic, SHMT, Glycine hydroxymethyltransferase, Serine methylase, SHMT1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  462184

• Physical Properties:

  Liquid