S1PR5 Antibody

• Background:

  The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.

• NCBI Gene ID:

  53637

• Swiss Prot:

  Q9H228

• Accession Number:

  Q9H228

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This S1PR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human S1PR5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  S1PR5

• NCBI Official Name:

  Sphingosine 1-phosphate receptor 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chang, C.L., et al. Am. J. Physiol., Cell Physiol. 297 (2), C451-C458 (2009) :

• Background Reference 02:

  Gillies, L., et al. Cell. Signal. 21 (5) :675-684 (2009)

• Background Reference 03:

  Miron, V.E., et al. Ann. Neurol. 63 (1) :61-71 (2008)

• Background Reference 04:

  Ulfig, N., et al. Acta Histochem. 106 (5) :373-378 (2004)

• Other Product Names:

  Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8

• Tested Applications:

  WB

• Protein ID:

  62510663

• Physical Properties:

  Liquid