S1PR2 Antibody

• Background:

  The Sphingosine 1-phosphate receptor 2 (S1PR2) protein was initially identified as G-protein coupled receptor thought to be involved in development (1) and was found to mediate sphingosine 1-phosphate (SPP) -induced cell rounding and neurite retraction (2) . S1PR2 and the related protein S1PR3 (also known as EDG3) are also thought to mediate the SPP-induced cell proliferation, survival, and related signaling events (3) . S1PR2 has also been found to be key regulator in acute vascular inflammation and may be a novel therapeutic target for vascular disorders (4) .

• NCBI Gene ID:

  9294

• Swiss Prot:

  O95136

• Accession Number:

  NP_004221

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell, Signal Transduction, Immunology

• Purification:

  S1PR2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  S1PR2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  S1PR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Observed Molecular Weight:

  Multiple transmembrane protein, also multiple other S1PR2 antibodies also show a ~50kD band

• Fragment:

  IgG

• Specificity:

  S1PR2 antibody is human, mouse and rat reactive.

• Symbol:

  S1PR2

• NCBI Official Name:

  Sphingosine-1-phosphate receptor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  MacLennan AJ, Browe CS, Gaskin AA, et al. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol. Cell Neurosci. 1994; 5:201-9.

• Background Reference 02:

  Van Brocklyn JR, Tu Z, Edsall LC, et al. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. J. Biol. Chem. 1999; 274:4626-32.

• Background Reference 03:

  An S, Zheng Y, and Bleu T. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biol. Chem. 275:288-96.

• Background Reference 04:

  Zhang G, Yang L, Kim GS, et al. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood 2013; 122:443-55.

• Other Product Names:

  Sphingosine 1-phosphate receptor 2, S1P2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  134244587

• Physical Properties:

  Liquid