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S1PR2 Antibody

CAT: 0223-8229-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8229-01Size:0.02 mg
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Background
The Sphingosine 1-phosphate receptor 2 (S1PR2) protein was initially identified as G-protein coupled receptor thought to be involved in development (1) and was found to mediate sphingosine 1-phosphate (SPP) -induced cell rounding and neurite retraction (2) . S1PR2 and the related protein S1PR3 (also known as EDG3) are also thought to mediate the SPP-induced cell proliferation, survival, and related signaling events (3) . S1PR2 has also been found to be key regulator in acute vascular inflammation and may be a novel therapeutic target for vascular disorders (4) .
NCBI Gene ID
9294
Swiss Prot
O95136
Accession Number
NP_004221
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Signal Transduction, Immunology
Purification
S1PR2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
S1PR2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
S1PR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Observed Molecular Weight
Multiple transmembrane protein, also multiple other S1PR2 antibodies also show a ~50kD band
Fragment
IgG
Specificity
S1PR2 antibody is human, mouse and rat reactive.
Symbol
S1PR2
NCBI Official Name
Sphingosine-1-phosphate receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
MacLennan AJ, Browe CS, Gaskin AA, et al. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol. Cell Neurosci. 1994; 5:201-9.
Background Reference 02
Van Brocklyn JR, Tu Z, Edsall LC, et al. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. J. Biol. Chem. 1999; 274:4626-32.
Background Reference 03
An S, Zheng Y, and Bleu T. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biol. Chem. 275:288-96.
Background Reference 04
Zhang G, Yang L, Kim GS, et al. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood 2013; 122:443-55.
Other Product Names
Sphingosine 1-phosphate receptor 2, S1P2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
134244587
Physical Properties
Liquid

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