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MARCH1 Antibody

CAT: 0223-57-661Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-661Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19) . MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]) .
NCBI Gene ID
55016
Swiss Prot
Q8TCQ1
Accession Number
Q8TCQ1
Host
Rabbit
Reactivity
Mouse
Immunogen
This MARCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human MARCH1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MARCH1
NCBI Official Name
E3 ubiquitin-protein ligase MARCH1
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Thibodeau, J., et al. Eur. J. Immunol. 38 (5) :1225-1230 (2008)
Background Reference 03
De Gassart, A., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (9) :3491-3496 (2008)
Background Reference 04
Bartee, E., et al. J. Virol. 78 (3) :1109-1120 (2004)
Other Product Names
E3 ubiquitin-protein ligase MARCH1, 632-, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, MARCH-I, RING finger protein 171, MARCH1, RNF171
Tested Applications
WB
Protein ID
74762613
Physical Properties
Liquid

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