TCEB2 Antibody

• Background:

  This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.

• NCBI Gene ID:

  6923

• Swiss Prot:

  Q15370

• Accession Number:

  Q15370

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-48 amino acids from the Central region of human TCEB2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  13 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TCEB2

• NCBI Official Name:

  Transcription elongation factor B polypeptide 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Marcsisin, S.R., et al. J. Mol. Biol. 402 (5) :892-904 (2010)

• Background Reference 02:

  Piessevaux, J., et al. J. Biol. Chem. 283 (31) :21334-21346 (2008)

• Background Reference 03:

  Van Herreweghe, E., et al. EMBO J. 26 (15) :3570-3580 (2007)

• Background Reference 04:

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Other Product Names:

  Transcription elongation factor B polypeptide 2, Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18, TCEB2

• Tested Applications:

  WB

• Protein ID:

  32699512

• Physical Properties:

  Liquid