TCEB3 Antibody

• Background:

  This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

• NCBI Gene ID:

  6924

• Swiss Prot:

  Q14241

• Accession Number:

  Q14241

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TCEB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human TCEB3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  90 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TCEB3

• NCBI Official Name:

  Transcription elongation factor B polypeptide 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Landa, I., et al. PLoS Genet. (9), E1000637 (2009) :

• Background Reference 02:

  Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)

• Background Reference 03:

  Woo, J.S., et al. EMBO J. 25 (6) :1353-1363 (2006)

• Background Reference 04:

  Andersen, J.S., et al. Nature 433 (7021) :77-83 (2005)

• Other Product Names:

  Transcription elongation factor B polypeptide 3, Elongin 110 kDa subunit, Elongin-A, EloA, RNA polymerase II transcription factor SIII subunit A1, SIII p110, TCEB3

• Tested Applications:

  WB

• Protein ID:

  294862430

• Physical Properties:

  Liquid