TCEB3 Antibody

Elongin A (TCEB3), which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits.This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

6924

Q14241

NP_003189

Human, Dog

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TCEB3.

Unconjugated

Primary Antibodies

Transcription, Cancer

Antibody is purified by protein A chromatography method.

Tranfected 293T Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TCEB3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

87 kDa

TCEB3 antibody can be used for detection of TCEB3 by ELISA at 1:62500. TCEB3 antibody can be used for detection of TCEB3 by western blot at 7.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

TCEB3

Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)

Homo sapiens

Beausoleil, S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135.

TCEB3, EloA, SIII, TCEB3A, SIII p110

ELISA, WB, IHC

208022641