CNOT2 Antibody

• Background:

  This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.

• NCBI Gene ID:

  4848

• Swiss Prot:

  Q9NZN8

• Accession Number:

  Q9NZN8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CNOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the Central region of human CNOT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CNOT2

• NCBI Official Name:

  CCR4-NOT transcription complex subunit 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lau, N.C., et al. Biochem. J. 422 (3) :443-453 (2009)

• Background Reference 02:

  Miyasaka, T., et al. Cancer Sci. 99 (4) :755-761 (2008)

• Background Reference 03:

  Morita, M., et al. Mol. Cell. Biol. 27 (13) :4980-4990 (2007)

• Background Reference 04:

  Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

• Other Product Names:

  CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2

• Tested Applications:

  WB

• Protein ID:

  46396017

• Physical Properties:

  Liquid