MCPH1 Antibody

• Background :

  This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.

• NCBI Gene ID :

  79648

• Swiss Prot :

  Q8NEM0

• Accession Number :

  Q8NEM0

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human MCPH1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  93 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  MCPH1

• NCBI Official Name :

  Microcephalin

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Wang, Y., et al. J. Hum. Genet. 55 (8) :490-494 (2010)

• Background Reference 02 :

  Ruano, G., et al. Pharmacogenomics 11 (7) :959-971 (2010)

• Background Reference 03 :

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04 :

  Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :

• Other Product Names :

  Microcephalin, MCPH1

• Tested Applications :

  WB

• Protein ID :

  296439305

• Physical Properties :

  Liquid