JAM2 Antibody

• Background:

  Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs. [provided by RefSeq].

• NCBI Gene ID:

  58494

• Swiss Prot:

  P57087

• Accession Number:

  P57087

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This JAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the N-terminal region of human JAM2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  JAM2

• NCBI Official Name:

  Junctional adhesion molecule B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Need, A.C., et al. Hum. Mol. Genet. 18 (23) :4650-4661 (2009)

• Background Reference 02:

  Ueki, T., et al. Microvasc. Res. 75 (2) :269-278 (2008)

• Background Reference 03:

  Weber, C., et al. Nat. Rev. Immunol. 7 (6) :467-477 (2007)

• Background Reference 04:

  Liu, T., et al. J. Proteome Res. 4 (6) :2070-2080 (2005)

• Other Product Names:

  Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM

• Tested Applications:

  WB, IHC-P

• Protein ID:

  10720348

• Physical Properties:

  Liquid