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JAM-A Recombinant Protein

CAT: 0223-91-423Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-423Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.
CAS Number
9000-83-3
NCBI Gene ID
50848
Swiss Prot
Q9Y624
Accession Number
Q9Y624
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl, 50mM NaCl, 100mM Glycine, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
23.89 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
F11 receptor
NCBI Organism
Homo sapiens
Other Product Names
Junctional Adhesion Molecule A, JAM-A, Junctional Adhesion Molecule 1, JAM-1, Platelet F11 Receptor, Platelet Adhesion Molecule 1, PAM-1, CD321, F11R, JAM1, JCAM, F11 Receptor
Species
Human
Physical Properties
Lyophilized

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