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NR2E3 Antibody

CAT: 0223-57-558Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-558Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI Gene ID
10002
Swiss Prot
Q9Y5X4
Accession Number
Q9Y5X4
Host
Rabbit
Reactivity
Human
Immunogen
This NR2E3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the Central region of human NR2E3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NR2E3
NCBI Official Name
Photoreceptor-specific nuclear receptor
NCBI Organism
Homo sapiens
Background Reference 01
Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)
Background Reference 02
Yang, Y., et al. Invest. Ophthalmol. Vis. Sci. 51 (4) :2229-2235 (2010)
Background Reference 03
Khan, A.O., et al. Arch. Ophthalmol. 128 (3) :344-348 (2010)
Background Reference 04
Kanda, A., et al. Mol. Vis. 15, 2174-2184 (2009) :
Other Product Names
Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor, NR2E3, PNR, RNR
Tested Applications
WB
Protein ID
8928275
Physical Properties
Liquid

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