TRAP1 Antibody

• Background:

  HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. TRAP1 is a mitochondrial HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and endoplasmic reticulum (HSP90B1; MIM 191175) (Chen et al., 2005 [PubMed 16269234]) .

• NCBI Gene ID:

  10131

• Swiss Prot:

  Q12931

• Accession Number:

  Q12931

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 542-570 amino acids from the C-terminal region of human TRAP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  80 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TRAP1

• NCBI Official Name:

  Heat shock protein 75 kDa, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, D., et al. Cancer Lett. 296 (2) :194-205 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Nguyen, M.C., et al. Cancer Immunol. Immunother. 59 (9) :1313-1323 (2010)

• Background Reference 04:

  Landriscina, M., et al. Cancer Res. 70 (16) :6577-6586 (2010)

• Other Product Names:

  Heat shock protein 75 kDa, mitochondrial, HSP 75, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1, TRAP1, HSP75

• Tested Applications:

  WB, IHC-P

• Protein ID:

  67477458

• Physical Properties:

  Liquid